Abstract # P-127 Role of T-Cells in Limbal Stem Cell Allograft Rejection

Cox, Constance
Lakewood,, OH, USA

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About the Presenter:

Constance A. Cox, M.D.
Cleveland Clinic Foundation
Cleveland, OH 44107

Research Interests:
Limbal stem cell transplant inflammation/pterygia/cell biology/translational/pharmacology/angiogenesis/matrix metalloproteinases/migration

Research Experience:
Murine Corneal Limbal Stem Cell Transplant Model, transplant rejection and inflammation; (please see poster).

Pterygial epithelial cells induce angiogenesis and doxycycline inhibits angiogenesis derived from these cells in the mid-range concentration using the directed in vivo angiogenesis assay.

Doxycycline inhibits the Migration of Cultured Pterygial Epithelial Cells. Doxycycline’s matrix metalloproteinase inhibitory effects were able to decrease the migration of cultured pterygial epithelial cells & dermal microvascular endothelial cells as measured by the Boyden Chamber Migration Assay. Zymography demonstrated a reduction of MMP 9 and 2 with doxycycline.

The effects of trypan blue and indocyanine green (ICG) on cultured retinal pigment epithelial (rpe) cells. The results of this study show that both dyes are toxic to rpe cells, although ICG is more so, especially in the presence of light.

Diagnosis and management of hereditary benign intraepithelial dyskeratosis (HBID).This focuses on the use of conjunctival impression cytology to diagnose HBID, as well as the use of immunosuppressants to treat it.

Medical care for the homeless: a practical approach to an academic problem. This clinical study investigated the economic burden of the homeless on six Philadelphia hospitals, and the most efficient means of providing care for these patients.

Variation in alcohol dehydrogenase activity and flood tolerance in white clover, trifolium repens. The regulation of genes controlling enzyme activity and the biochemical adaptation of white clover to the environmental stress of flooding was investigated.

Service: Free Clinic of Greater Cleveland: Ophthalmology; Fellows’ retreat committee at NIH


Medical School: University of Pennsylvania
Ophthalmology Residency: University of Minnesota
Research Fellowship: NIH/NEI
Clinical Fellowship: CCF

Cox, Constance A.; Perez, Victor L.

Cleveland Clinic Foundation
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