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About the Presenter:
Born in Loebau, Germany, Matthias Mueller completed in 1995 a programme for technical training in the field of electricity, in a company specialized in the production of devices used in the construction of large sized electrical engines. After obtaining his technical diploma, he performed diverse civilian services in a welfare center involving support to elderly patients. In 1997, he started studies on medical physics at the Technische Fachhochschule Berlin - University of Applied Science. Within his diploma thesis, M. Mueller developed a flexible applicator for Laser-induced Thermotherapy. The applicator was mounted in front of a 400 µm quartz fiber and consisted of a temperature stable plastic material with deposited scattering particles. It provided a homogeneous axial scattering profile over an active length of 30 mm. The maximum power settings were tested in porcine liver (in vitro) using a Nd:YAG-Laser and a cooled protective catheter. They were found to be 31 W over an exposure period of 10 minutes. The resulting thermal lesions showed axial extensions of up to 50 mm and diameters of up to 33 mm, representing a total volume of 28.6 cm³. The concept of this novel laser applicator was published in the peer-reviewed literature (Knappe V, Roggan A, Glotz M, Mueller M, et al. New flexible Applicators for Laser-induced Thermotherapy. Med Laser Appl 2001; Aug:1673-1680), and has been patented afterwards. In 2002 he finished his diploma with an "honourable mention".
His interest in Ophthalmology started during an internship in the Eye Clinic of the Humboldt University/Virchow Klinikum, which was a requirement of the main medical physics curriculum of the Technische Fachhochschule Berlin - University of Applied Science. From 2002 to 2004, he worked in the laser laboratory of this clinic as a scientific assistant, providing support to eye doctors who worked on diverse research projects. He was also the supervisor of the excimer laser surgeries at the clinic. During this period, M. Mueller“s main research project was on the development of a method to prepare donor grafts for transplantation applying excimer laser techniques. Basically, the beam of an experimental excimer laser was homogenized and guided by an optical system including lenses and scanner mirrors. A special software was used to conduct the laser beam in a circular mode over the surface of the cornea. The system was tested on corneas from porcine eyes, which were stabilized in an artificial anterior chamber. The experiments showed the possibility of non-contact trephination and generation of smooth cut edges with a rotating focussed excimer laser beam in a porcine cornea model. A major advantage of the system is the possibility of customized "tailored" grafts (Mueller M, Sherif Z, Pleyer U, Hartmann C. Non-contact donor cornea trephination with a flying spot excimer laser system. Ophthalmologe 2005 Feb; 102:163-169).
In 2004 he started working at the Eye Clinic Spreebogen, directed by Prof. Manfred Tetz, where he coordinates all clinical trials and provides assistance regarding most of the technical devices. In the Berlin Eye Research Institute (BERI), Matthias Mueller is responsible for the computerized infrastructure and other technical aspects of different research projects. Furthermore, he organises wet labs and provides support to medical doctoral candidates and trainees.
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Authors:
Mller, Matthias; Werner, Liliana; Langenbeck, Julia; Tetz, Manfred R.
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Institutions:
Berlin Eye Research Institute
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Titel, Authors, Institutions:
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